Acts 13:14-16

They came to Antioch. They seemed to have passed at once from Perga to the Antioch that lay in the interior. It must be distinguished from the Antioch of Syria before named (Ac 11:22). There were several Antiochs, this one being the capital of the province of Pisidia. Vast ruins still mark its site.

Went into the synagogue. In every Gentile city where there was a Jewish synagogue the gospel was preached first to the Jews by the apostolic preachers. The course of Paul and Barnabas here is an example of their custom.
After the reading. In the synagogue worship the reading of the Scriptures made a very important part. As copies of the Scriptures were very rare, this reading was necessary to convey scriptural instruction to the people. They were read in course, two lessons each Sabbath, one from the five books of Moses, the other from the other books of the Old Testament. Plummptree insists that we are enabled by two curious coincidences to fix, with very little uncertainty, the precise Sabbath on which the mission work at Antioch opened. The opening words of Paul refer to De 1:31, and this was the lesson for the forty-fourth Sabbath in the year, which fell in July or August; the corresponding second lesson from the prophets being Isa 1:1-27, from which he also quotes. He starts, as was natural, from what the people had just been listening to, as the text of his discourse.

The rulers of the synagogue. The synagogue was governed by a board of elders.
Then Paul stood up. Invited to speak by the usual courtesy extended to visiting brethren, he arose, according to the Greek custom. In Judea speakers sat. Among the Greeks they stood. The address that follows, the first reported address of Paul, is worthy of special study especially as an example of the character of his preaching in the synagogue. It begins with a short recapitulation of the glorious history of Israel, a theme always apt to secure the favor of a Jewish audience, and when he has ascended to David, the hero king and the pride of every Jew, he passes from him to the promised Son of David, and thus preaches Christ. Had he begun at once with the latter, the great object of his discourse, he would have aroused prejudice and perhaps closed their ears. It will be observed here before a Jewish audience, as well as at Athens before a heathen audience, he first secured a common ground with his hearers, and upon it founded his argument for the gospel.

Men of Israel, and ye that fear God. There were two classes present, Jews and "the devout Greeks". The latter had given up heathenism, had learned to "fear God", and were anxious to learn more about him; hence were wont to attend the synagogue.
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